Persistent Fatigue and the Gut: A Review of the Evidence
What published studies say about the gut, sleep and energy, and the questions they raise.
Prepared by the Manna Honey editorial team · Sources linked in the references
Summary
Finding 1. The vagus nerve connects the gut to the brain and is involved in appetite, mood and immune regulation (Browning et al., Gastroenterology, 2017).
Finding 2. Spore-forming gut bacteria promoted serotonin production in mice (Yano et al., Cell, 2015).
Finding 3. Sleep and the gut microbiota influence each other (PubMed 35032622).
Finding 4. A probiotic strain has to survive stomach acid to matter. B. coagulans MTCC 5856 showed higher resistance to simulated gastric juice than Lactobacillus strains in a lab study (PubMed 33580694).
Interpretation
Fatigue is usually assessed through mood, sleep and blood work. The studies above suggest a fourth channel worth looking at: the gut and its link to the brain.
Application
Manna Gut Honey was formulated around these findings: a spore-forming probiotic, slippery elm, L-glutamine and raw honey, taken once each morning.
Try Manna Gut HoneyReferences
Browning KN et al. Gastroenterology 2017. PubMed 27988382
Yano JM et al. Cell 2015. PubMed 25860609
Sleep and the gut microbiota. PubMed 35032622
B. coagulans MTCC 5856. PubMed 33580694
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